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KMID : 1134820070360050527
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 5 p.527 ~ p.533
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A Study on Single Oral Dose Toxicity of Highly?Developed Anthocyanin?Pigmented Rice Varieties
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Han Hye-Kyoung
Choi Sung-Sook
Shin Jin-Chul
Chung Ha-Sook
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Abstract
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The present study was carried out to investigate the potential toxicity of highly?developed rice varieties, Oryza sativa cvs. Jukjinjubyeo, Heugjinjubyeo and Heughyangbyeo by a single oral dose in ICR mice. The test article was orally administered once by gavage at dose levels of 0, 2.5, 5.0, and 10.0 g/㎏ body weight (n=10 for male and female mice for each dose). We examined the number of deaths, general clinical signs, body weights and biochemical analysis for sexes and doses of mice between control and experimental groups. As a result, all of the groups were alive during experimental periods and none of the significant clinical symptom and body weight changes were shown in all of the groups. Plasma glucose levels were valued for both control and experimental groups and there were no significant differences between the groups. The activities of aminotransferase were not increased in all experimental groups compared to control groups. The results suggest that the toxicity of the aleurone layer of Oryza sativa cvs. Jukjinjubyeo, Heugjinjubyeo and Heughyangbyeo are low and its LD?? is over 10.0 g/㎏ body weight in both male and female mice.
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KEYWORD
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Jukjinjubyeo, Heugjinjubyeo, Heughyangbyeo, ICR mice, single oral dose toxicity, lethal dose, food safety
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